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Could next generation amyloid ligands become de facto standards? Hitoshi Shimada 1 1Brain Disorder Translational Research Team Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Keyword: アミロイドPET , 18F-NAV4694 , 18F-FPYBF-2 , 18F-F12 , 18F-SLOH pp.1193-1198
Published Date 2020/10/10
DOI https://doi.org/10.18888/rp.0000001416
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Amyloid-βdeposits, which are pathognomonic hallmarks of Alzheimer’s disease in addition to neurofibrillary tangles, are a pivotal target for imaging as well as therapy. Even recently, novel amyloid PET ligands have been under development. Some ligands show lower off-target binding to white matter compared with conventional ones, leading to the realization of the early possible detection of subtle Aβdeposition. If disease modifying agents are approved in the near future, preclinical diagnosis by PET with novel ligands will become increasingly important. Key issues for novel amyloid PET ligands, which are needed to become the de facto standard, include “standardization” and “neuroimaging-pathological correlation”.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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