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History of tau PET ligand development Ryuichi Harada 1 , Nobuyuki Okamura 2 1Department of Pharmacology Tohoku University Graduate School of Medicine 2Division of Pharmacology, Faculty of Medicine Tohoku Medical and Pharmaceutical University Keyword: タウPET , 18F-Flortaucipir , アルツハイマー病 pp.317-325
Published Date 2021/4/10
DOI https://doi.org/10.18888/rp.0000001564
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Recently,[18F]Flortaucipir(TauvidTM,[18F]AV-1451,[18F]T807)was approved by Food Drug Administration in US to estimate the density and distribution of aggregated tau neurofibrillary tangles in adult with cognitive impairment who are evaluated for Alzheimer’s disease. Many tau PET tracers have been developed by academia and pharma and tested in humans over the last 10 years. Although tau PET tracers are designed to detect aggregated tau neurofibrillary tangles found in Alzheimer’s disease, they possess different binding affinity, different binding sites, different pharmacokinetics, and different degree of off-target binding. In this chapter, we will review the history of the development of tau PET tracers and the current status of tau PET radiopharmaceuticals.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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