アミロイドPETの臨床実装—アルツハイマー病の診断と治療における最新知見と実践的アプローチ

Clinical Implementation of Amyloid PET: Latest Findings and Practical Approaches in the Diagnosis and Treatment of Alzheimer's Disease

アミロイドPETは，アルツハイマー病の早期診断と疾患修飾薬の適応判断において重要な役割を果たす。高感度・特異度，低侵襲性，空間的評価能力といった利点をもち，認知症医療の最適化に貢献するが，限界を理解したうえでの適切な使用と結果の解釈が不可欠である。無症候者への適応には慎重な判断が必要だが，前臨床期における先制医療や個人の高精度リスク推定が確立すれば，臨床的意義がさらに拡大する可能性がある。

Abstract

Amyloid PET plays a crucial role in the early diagnosis of Alzheimer's disease and the determination of the feasibility of disease-modifying therapies. It offers several advantages, including high sensitivity and specificity, minimal invasiveness, and the ability to provide spatial evaluation, all of which contribute to the optimization of dementia care. However, proper use and interpretation of the results require a thorough understanding of their limitations. Although careful consideration is necessary when using scans on asymptomatic individuals, clinical applications could broaden if preemptive treatments and high-precision individual risk assessments for the preclinical stage are developed.