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Amyloid PET imaging for brain Kazunari Ishii 1 1Department of Radiology Kindai University Faculty of Medicine Keyword: アミロイドPET , 保険適用 , 頭部専用PET装置 pp.177-188
Published Date 2025/3/10
DOI https://doi.org/10.18888/rp.0000002853
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Alzheimer’s disease(AD)is the most common cause of dementia. Newly approved anti-amyloid beta(Aβ)therapies, such as lecanemab and donanemab, have made amyloid PET essential for confirming cerebral Aβ deposition. Three 18F-labeled radiopharmaceuticals(florbetapir, flutemetamol, and florbetaben)are clinically available in Japan with standardized interpretation protocols. While amyloid PET can visualize Aβ noninvasively, a positive scan does not necessarily imply AD-related cognitive impairment. For accurate diagnosis, visual interpretation must adhere to established guidelines, and quantitative indices(SUVR or Centiloid scale)may help refine assessments. Recently, dedicated brain PET systems(e.g., BresTome® and Vrain®)have emerged, offering higher spatial resolution for brain PET imaging.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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