ビマトプロスト単回点眼の正常眼における視神経乳頭血流に及ぼす影響

Changes in optic disc circulation in normal eyes following single instillation of bimatoprost

要約　目的：ビマトプロストによる単回点眼が正常眼での乳頭血流に及ぼす影響の報告。対象と方法：男性4名と女性4名の正常篤志者8名を対象とした。年齢は24～44歳，平均34歳で，屈折は0～－7D，平均－3.25Dであった。片眼に0.03％ビマトプロスト，僚眼に生理食塩水を点眼し，270分後までの乳頭血流量をレーザースペックル法で測定した。血流量測定は，乳頭を上方，下方，鼻側，耳側と4分割して行った。結果は二重盲検法で解析した。結果：乳頭血流量は，点眼から90分後に乳頭耳側で増加し，これ以後と他の象限では有意な変化はなかった。眼圧は点眼から180分後と270分後に有意に低下し，僚眼では変化がなかった。眼灌流圧は，点眼から180分後と270分後に有意に増加した。結論：ビマトプロストの点眼で，乳頭血流が増加する可能性がある。

Abstract.　Purpose：To report the effect of single instillation of bimatoprost on the circulation of normal optic nerve head. Cases and Method：This prospective study was made on 8 healthy adults. The series comprised 4 males and females each. The age ranged from 24 to 44 years and averaged 34 years. Refraction ranged from zero to －7 diopters, average －3.25 diopters. Each subject was instilled with 0.03％ ophthalmic solution of bimatoprost in one eye. The fellow eye was instilled with physiological solution and served as control. Circulation in the optic nerve head was measured by laser speckle flowgraphy for each quadrant. Findings were analyzed by double blind method. Results：Blood flow in the optic nerve head increased significantly in the temporal quadrant 90 minutes after instillation. There was no change after 180 or 270 minutes nor in other quadrants. Intraocular pressure decreased significantly and ocular perfusion pressure increased significantly 180 and 270 minutes after instillation. Conclusion：Circulation in the optic nerve head may increase after instillation of bimatoprost.