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Japanese

Long-term effect of instillation of levobunolol on microcirculation of the human fundus Sumiko Kajiura 1 , Tetsuya Sugiyama 1 , Shota Kojima 1 , Mari Ueki 1 , Norihiko Hirotsuji 1 , Masayuki Nakajima 1 , Tsunehiko Ikeda 1 1Dept of Ophthalmol,Osaka Med Coll pp.1841-1845
Published Date 2006/10/15
DOI https://doi.org/10.11477/mf.1410100959
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Abstract. Purpose:To report the long-term effect of topital levobunolol on microcirculation of the fundus. Object and Method:This study was made on 6 healthy male volunteers. Their age ranged from 28 to 56 years,average 33 years. Laser speckle method was used to quantitate the circulation in the optic disc and choroid-retina,with normalized blur(NB)serving as the indicator. Each test person was measured as to NB,intraocular pressure(IOP)and blood pressure before and after instillation of physiological saline to obtain baseline values. Test persons then received 0.5% levobunolol twice daily in one eye and physiological saline in the other for 3 weeks. The obtained data were processed as double-blind. Results:There were significant increases in NB values of optic disc and choroid-retina before instillation on day 21 of experiment. IOP decreased in both eyes. There was no change in blood or ocular perfusion pressure. Conclusion:Instillation of levobunolol for 3 weeks induces increased microcirculation in the fundus,probably due to decreased resistance of blood vessels by α1 blocking action.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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