原発開放隅角緑内障に対するタフルプロスト3年間点眼の視神経乳頭・形状，視野に及ぼす影響

Effects on visual field, morphology and microcirculation of optic nerve head following tafluprost treatment for 3 years in patients with glaucoma

要約　目的：原発開放隅角緑内障眼（POAG）に対するタフルプロストの3年間点眼が，視神経乳頭血流，視野，視神経乳頭形状に及ぼす影響の報告。対象および方法：広義のPOAG 24例を対象とし，無作為割付を行い11例にタフルプロスト（T群），13例にラタノプロスト（L群）を3年間点眼した。全例で眼圧，レーザースペックル法による乳頭微小循環，視野，乳頭形状などの測定を行った。結果：両群で同等の眼圧下降効果を認めた。上方，下方，耳側の乳頭血流がL群で減少したが，T群では有意な減少はなかった。Humphrey視野のMD値，乳頭形状や網膜神経線維層厚は期間中，両群で有意な変化がなかった。結論：3年間の点眼により，タフルプロストはラタノプロストと異なり，乳頭血流を維持した。

Abstract.　Purpose：To report the 3-year effect of tafluprost treatment on visual field, morphology and microcirculation of optic nerve head in patients with primary open-angle glaucoma（POAG）. Cases and Method：A randomized comparative study was made on 24 patients with POAG. 11 patients treated by tafluprost and 13 patients treated by latanoprost. They were followed up for 3 years regarding intraocular pressure（IOP）, shape and microcirculation of optic nerve head measured by laser speckle and visual field. Results：IOP in both groups decreased significantly after instillation over 3 years and there was no change between the two groups in the IOP reduction rate. In eyes treated by latanoprost, microcirculation of optic nerve head significantly decreased except in the nasal sector, but no decrease was found in eyes treated by tafluprost. There was no change in MD value measured by Humphrey or findings by optical coherence tomography and Heidelberg retina tomograph Ⅱ. Conclusion：The IOP-lowering effect of tafluprost was similar to that of latanoprost. Microcirculation of optic nerve head was kept for 3 years in patients treated by tafluprost, but decreased in patients treated by latanoprost.