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Changes in visual field, morphology and microcirculation of the optic nerve head after instillation of tafluprost for one year Shota Kojima 1 , Tetsuya Sugiyama 1 , Maho Shibata 1 , Mari Ueki 1 , Ryosuke Komoto 1 , Tsunehiko Ikeda 1 1Dept of Ophthalmol, Osaka Med Coll pp.895-902
Published Date 2014/6/15
DOI https://doi.org/10.11477/mf.1410105283

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Abstract. Purpose:To report the one-year effect of tafluprost instillation on visual field, shape and microcirculation of optic nerve head in eyes with primary open-angle glaucoma(POAG). Cases and Method:This prospective study was made on 25 patients with POAG. These cases were randomly divided into 2 groups. Twelve cases received instillation of 0.0015% tafluprost. The other 13 cases received 0.005% latanoprost. They were followed up for one year regarding intraocular pressure(IOP), shape and microcirculation of optic nerve head as measured by laser speckle, and visual field. Results:IOP decreased 1 to 12 months after start of instillation in both groups. MD value measured by Humphrey perimeter increased significantly only in eyes treated by tafluprost. Microcirculation in the optic nerve head increased significantly in superior and interior sectors in cases treated by tafluprost. It decreased significantly in inferior and temporal sectors in cases treated by latanoprost. There was no change in blood pressure, perfusion pressure of the eye, or findings by optical coherence tomograph(OCT)and Heidelberg retina tomograph(HRT)Ⅱ. Conclusion:Topical instillation of tafluprost for one year may result in increased microcirculation of the optic nerve head in eyes with POAG.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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