緑内障眼のラタノプロスト点眼からタフルプロスト点眼への切替えによる乳頭血流変化

Changes in the optic nerve head microcirculation after switching from topical latanoprost to tafluprost in eyes with glaucoma

要約　目的：ラタノプロストからタフルプロスト点眼に切替えたときの緑内障眼での乳頭微小循環の変化の報告。対象と方法：広義の原発開放隅角緑内障20例20眼を対象とした。年齢は43～78歳（平均66歳）である。ラタノプロスト点眼中とタフルプロストに切替えてから1か月と3か月後に乳頭の微小循環を，乳頭全体と上下の耳鼻側で測定した。測定にはレーザースペックル血流計を用い，mean blur rateを指標とした。結果：眼圧，血圧，眼灌流圧には切替え前後で差がなかった。血流量は，切替えの3か月後に乳頭の各部位で有意に増加した（p＝0.005～0.048）。結論：ラタノプロストからタフルプロスト点眼に切替えてから3か月後に，緑内障眼での乳頭微小循環が有意に増加した。

Abstract.　Purpose：To report changes in microcirculation of optic nerve head after switching from topical latanoprost to tafluprost in eyes with glaucoma. Cases and Method：This study was made on 20 eyes of 20 patients treated by topical latanoprost for primary open-angle glaucoma. The age ranged from 43 to 78 years,average 66 years. Microcirculation in the optic nerve head was measured before,one and 3 months after switching to tafluprost. Laser speckle flowmetry was used in the measurement with mean blur rate serving as the indicator. Measurement was made on the optic nerve head as a whole and in each of 4 sectors. Results：There was no change in intraocular pressure,ocular perfusion pressure,systemic blood pressure,or pulse rate after switching. Microcirculation of optic nerve head increased significantly 3 months after switching（p＝0.005～0.048 depending on the site of optic nerve head）. Conclusion：Microcirculation in the optic nerve head increased significantly 3 months after switching from topical latanoprost to tafluprost in eyes with glaucoma.