The Effectiveness of Indomethacin in a Patient with Bartter's Syndrome whose Urinary Prostaglandin ELevel was within Normal Range:A case report Mitunori Ohtsubo 1 , Kazuya Yonezawa 1 , Kohichi Okita 1 , Akiko Hanada 1 , Yutaka Fujiwara 2 , Kyoichi Hosokawa 2 , Fumihiro Honmura 2 , Tohru Shimizu 2 , Hideaki Takei 2 , Hisashi Nishihara 2 , Isao Sato 3 , Yuichiro Fukasawa 4 , Akira Kitabatake 4 1Department of Cardiovascular Medicine, Hokkaido University School of Medicine 2Department of Internal Medicine, Bibai Rousai Hospital 3Department of Cardiovascular Medicine, Bibai Rousai Hospital 4Department of Pathology, Sapporo City General Hospital Keyword: Bartter症候群 , indomethacin , 尿中PG-E , Bartter's syndrome , urinary prostaglandin E pp.407-410
Published Date 1997/4/15
DOI https://doi.org/10.11477/mf.1404900036
  • Abstract
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Bartter's syndrome, which was first reported by Bart-ter in 1962, is a kind of secondary aldosteronism. As the cause of this syndrome, some hypotheses such as hyper-production of prostaglandin, impaired chloride reabsor-ption are suggested and correlation of many factors is also considered. It has been reported that urinary pros-taglandin (PG) E level is high in indomethacin effective cases. There are few reports of indomethacin effective cases with normal urinary PG-E level. Our patient with Bartter's syndrome, whose urinary PG-E was within normal level, has shown improvements in plasma renin activity and plasma aldosterone concentration under indomethacin therapy. We suggest that indomethacin should be administered in patients with Bartter's syn-drome regardless of urinary PG-E.

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