Mitochondrial function in migraine. Tokio SHIMOMURA 1 , Kazuhiko KOTANI 1 , Fumiyo MURAKAMI 1 1Department of Clinical Laboratory Medicine, Faculty of Medicine, Tottori University Keyword: oxidative phosphorylation , magnesium , riboflavion , MELAS , superoxide dismutase pp.391-396
Published Date 2002/6/10
DOI https://doi.org/10.11477/mf.1431901362
  • Abstract
  • Look Inside

Like many other neurological diseases, mitochondrial involvement, by means of abnormalities in cerebral oxidative metabolism, may play a role in migraine. A derangement of brain energy metabolism has been observed in patients affected by migraine using magnetic resonance spectroscopy (MRS) studies. Some abnormalities in mitochondrial respiratory chain enzyme activities also have been observed in muscles and platelets of patients with migraine. Platelet superoxide dismutase concentration and activity decreased in patients with migraine. These findings suggest vulnerability of oxidative stress in patients with migraine.

Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院