BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 71, Issue 6 (June 2019)
Japanese

Role of Complements in the Pathogenesis of Alzheimer's Disease Hidekazu Tomimoto 1 , Haruhiko Akiyama 2 1Department of Neurology, Mie University Graduate School of Medicine 2Department of Clinical Research, Yokohama Brain and Spine Center Keyword: 補体 , アミロイドβ , 認知症 , アルツハイマー病 , complement , amyloid β , dementia , Alzheimer's disease pp.589-596
Published Date 2019/6/1
DOI https://doi.org/10.11477/mf.1416201321
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Abstract

Complements are deposited in senile plaques, neurofibrillary tangles, and blood vessels. Microglia is activated around these structures and induce chronic inflammation through a cross talk between microglia and astroglia. Complements activated by amyloidβ (Aβ) bind to complement receptor (CR3) and help phagocytosis of the aggregated Aβ via opsonization of the aggregated Aβ. Inflammation in capillary cerebral amyloid angiopathy (CAA) may suppress Aβclearance and trigger a vicious cycle aggravating CAA.


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基本情報

18816096.71.6.jpg
BRAIN and NERVE-神経研究の進歩
71巻6号 (2019年6月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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