BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 64, Issue 5 (May 2012)
Japanese

Biomarkers for Alzheimer's Disease: After Alzheimer's Disease Neuroimaging Initiative Studies Mikio Shoji 1 1Department of Neurology,Hirosaki University Graduate School of Medicine Keyword: dementia , Alzheimer's disease , amyloid β , tau , amyloid β oligomer pp.497-504
Published Date 2012/5/1
DOI https://doi.org/10.11477/mf.1416101185
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Abstract

 Recent advances in biomarker studies compiled from the Alzheimer's Disease Neuroimaging Initiative (ADNI) are summarized here. CSF Aβ42,total tau,and phosphorylated tau181 are the most sensitive biomarkers for diagnosing Alzheimer's disease (AD) and predicting the onset of AD in cases with mild cognitive impairment (MCI) due to AD. Many perspective studies on PiB-PET,FDG-PET,MRI volumetry,and some neuropsychiatric tests have provided evidence for the usefulness of these biomarkers for diagnosing AD and MCI due to AD. Basic and clinical studies have contributed considerably to the establishment of clinical evidence that supports the usefulness of these markers. Given the progress in the diagnosis of preclinical AD,discovery of therapy that is essential for the cure of AD is expected soon.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

基本情報

18816096.64.5.jpg
BRAIN and NERVE-神経研究の進歩
64巻5号 (2012年5月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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