BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 66, Issue 11 (November 2014)

Confluence of Dementia and Epilepsy Pathologies Atsushi Iwata 1,2 1Department of Neurology, The University of Tokyo Hospital 2Japan Science and Technology Agency PRESTO Keyword: 認知症 , てんかん , アルツハイマー病 , アミロイドβ , 可塑性 , dementia , epilepsy , Alzheimer's disease , amyloid beta , plasticity pp.1379-1384
Published Date 2014/11/1
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Epilepsy in patients with Alzheimer's disease (AD) is not a mere complication of another common disease, but a result of synaptic dysfunction due to accumulation of toxic amyloid β (Aβ). An epileptic attack triggers formation of a new neuronal circuit to lower the threshold of the next attack, which is a result of inherent neuronal plasticity. In patients with AD, this plasticity is impaired such that a "seizures beget seizures" situation does not occur. Thus, patients with epilepsy in AD often respond well to medication.

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BRAIN and NERVE-神経研究の進歩
66巻11号 (2014年11月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院