BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 66, Issue 7 (July 2014)

Alzheimer's Disease: A Type of Cerebral Amyloidosis Mikio Shoji 1 1Department of Neurology, Hirosaki University Graduate School of Medicine Keyword: 認知症 , アルツハイマー病 , βアミロイド , タウ , アミロイドβオリゴマー , demantia , Alzheimer's disease , Aβ amyloid , tau , Aβ oligomer pp.837-847
Published Date 2014/7/1
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Alzheimer's disease is a slowly progressive dementia that is characterized by Aβ amyloid aggregation, neurofibrillary tangles, and neuronal death. The major clinical symptoms are memory disturbance, aphasia, visuospatial disturbance, disturbance of executive function, and behavioral changes. Diagnosis is defined by the presence of dementia, the exclusion of non-Alzheimer type dementia, progressive atrophy of the hippocampus and temporoparietal cortex, decreased blood flow and glucose metabolism in the posterior cingulate gyrus and precuneus, decreased levels of Aβ42, and increased levels of tau in the cerebrospinal fluid accompanied by positive amyloid proton emission tomography. The development of disease modifying drugs is desired.

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BRAIN and NERVE-神経研究の進歩
66巻7号 (2014年7月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院