アレルギー性結膜疾患における涙液サイトカイン濃度

Cytokine levels in the tear fluid in allergic conjunctivital diseases

（B5-2-4）　アレルギー性結膜疾患における複数の涙液サイトカイン濃度を比較検討した。アレルギー性結膜炎（AC），アトピー性角結膜炎（AKC），春季カタル〔（VKC）のうちアトピー性皮膚炎（AD）合併例は70％〕および正常対照者から採取した涙液インターロイキン（IL）-2,IL-4およびIL-5濃度をELISA法で測定した。涙液IL-2濃度は各群問に有意差はなかった。涙液IL-4はVKC群がACおよび対照群に対し，またAD合併VKC群がAD非合併VKC群に対し有意に高値であったが，VKC群とAKC群に差はなかった。涙液IL-5はAD合併にかかわらずVKC群で高値を示し，AKC,ACおよび対照群に対し有意に高かった。これらの結果から，IL-4とIL-5のアレルギー性結膜疾患の種類によって異なる動態が示された。

We quantitated cytokines, or interleukins (II) , in the tear fluid in 46 patients with allergic conjunctival diseases. The series comprised allergic conjunctivitis 13 cases, atopic keratoconjunctivitis 13 cases, and vernal keratoconjunctivitis 20 cases including 14 cases of atopic dermatitis. Another series of 12 healthy persons served as control. Levels of interleukins were measured using ELISA method. There was no difference in the levels of 11-2 among the four groups. Level of 11-4 was significantly higher in vernal keratoconjunctivitis than allergic conjunctivitis and controls. It was also higher in cases of vernal keratoconjunctivitis with atopic dermatitis than in those without. There was no difference between vernal and atopic keratoconjunctivitis. Level of 11-5 was significantly higher in cases of vernal keratoconjunctivitis with or without atopic dermatitis than in the other 3 groups. The findings show the difference in tear levels of 11-4 and 11-5 among different allergic conjunctival diseases.