Plasma osteopontin levels in patients with allergic conjunctivitis or vernal keratoconjunctivitis Noriko Matsuura 1 , Eiichi Uchio 1 , Masatoshi Nakazawa 2 , Mutsuhiko Minami 2 , Toshimitsu Uede 3 , Koki Aoki 1,4 , Shigeaki Ohno 5 1Dept of Ophthalmol, Yokohama City Univ Sch of Med 2Immunol and Parasitol, Yokohama City Univ Sch of Med 3Section of Immunopathogenesis, Institution for Genetic Med, Hokkaido Univ 4Aoki Eye Clinic 5Dept of Ophthalmol, Hokkaido Univ Graduate Sch of Med pp.893-896
Published Date 2002/5/15
DOI https://doi.org/10.11477/mf.1410909110
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We quantitated the plasma osteopontin levels in 11 cases of allergic conjunctivitis, 18 cases of vernal keratoconjunctivitis and 12 normal persons using an enzyme immunoassay kit. The ages averaged 32 years in allergic conjunctivitis, 16 years in vernal keratoconjunctivitis and 30 years in normal controls. Plasma osteopontin levels were significantly elevated in allergic conjunctivitis and vernal keratoconjunctivitis than in controls (p < 0.05) . There was no difference between allergic conjunctivitis and vernal keratoconjunctivitis. Osteopontin levels were significantly higher in 10 patients of vernal keratoconjunctivitis with atopic dermati-tis than in 8 patients without. The findings show that osteopontin, which is an acidic glycoprotein and is a ma-jor binding ligand for integrins on cellular adhesion, may be related with allergic conjunctival diseases.

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