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Japanese

Serum levels of soluble intercellular adhesion molecules in patients of vernal keratoconjunctivitis or allergic conjunctivitis Shin-ya Ono 1 , Eiichi Uchio 1 , Zenro Ikezawa 2 , Shigeaki Ohno 1 1Dept of Ophthalmol, Yokohama City Univ Sch of Med 2Dept of Dermatol, Yokohama City Univ Sch of Med pp.1661-1665
Published Date 1999/9/15
DOI https://doi.org/10.11477/mf.1410906510
  • Abstract
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We quantitated the soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in the serum of patients using enzyme-linked immunoassay. The cases comprised 30 patients with vernal keratoconjunctivitis, 30 patients of allergic conjunctivitis and 20 normal persons. Atopic dermatitis was concomitantly present in 20 patients (67%) of vernal keratoconjunctivitis. Serum level of sICAM-1 was higher in patients of vernal keratoconjunctivitis with atopic dermatitis than others. Serum level of sVCAM-1 was higher in patients of vernal keratoconjunctivitis with or without atopic dermatitis than in controls. There was no difference in sICAM-1 and sVCAM-1 in patients of vernal keratoconjunctivitis as related to the severity of atopic dermatitis. The findings suggest that sVCAM-1 in the serum may serve as a marker to differentiate vernal keratoconjunctivitis from nonproliferative ocular allergic diseases.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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