春季カタルおよびアレルギー結膜炎における血清可溶性接着分子

Serum levels of soluble intercellular adhesion molecules in patients of vernal keratoconjunctivitis or allergic conjunctivitis

　血清中の可溶性マーカーであるsoluble intercellular adhesion molecule-1（slCAM-1）とsoluble　vascular cell adhesion molecule-1（sVCAM-1）濃度を，春季カタル30例，アレルギー結膜炎30例，正常人20例で測定した。春季カタル例のうち20例にアトピー性皮膚炎が合併していた。春季力タル群でのsICAM-1とsVCAM-1は，他の2群よりも有意に高かった。アレルギー結膜炎と正常群とには差はなかった。アトピー性皮膚炎を合併している春季カタル群でのsICAM-1値は，非合併群よりも有意に高かった。春季カタルでのsVCAM-1値は，アトピー性皮膚炎の有無に無関係であった。アトピー性皮膚炎の重症度は，sICAM-1とsVCAM-1値には相関しなかった。以上の所見は，sVCAM-1が春季力カタル臨床像の指標として有用である可能性を示す。

We quantitated the soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in the serum of patients using enzyme-linked immunoassay. The cases comprised 30 patients with vernal keratoconjunctivitis, 30 patients of allergic conjunctivitis and 20 normal persons. Atopic dermatitis was concomitantly present in 20 patients (67%) of vernal keratoconjunctivitis. Serum level of sICAM-1 was higher in patients of vernal keratoconjunctivitis with atopic dermatitis than others. Serum level of sVCAM-1 was higher in patients of vernal keratoconjunctivitis with or without atopic dermatitis than in controls. There was no difference in sICAM-1 and sVCAM-1 in patients of vernal keratoconjunctivitis as related to the severity of atopic dermatitis. The findings suggest that sVCAM-1 in the serum may serve as a marker to differentiate vernal keratoconjunctivitis from nonproliferative ocular allergic diseases.