Expression of vascular endothelial growth factor in surgically excised choroidal neovascular membranes Atsushi Otani 1 , Hitoshi Takagi 1 , Yuichiro Ogura 1 , Kiyoshi Suzuma 1 , Chikako Takagi 1 , Yoshihito Honda 1 1Dept of Ophthalmol, Kyoto Univ Hosp pp.947-949
Published Date 1998/5/15
DOI https://doi.org/10.11477/mf.1410905894
  • Abstract
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We performed immunohistochemical analysis on surgically excised choroidal neovascular membranes in four eyes. The specimen was obtained from one eye each with age-related macular degeneration, idiopathic macular degeneration, angioid streaks and high myopia. All the specimens contained immunoreactive cells for vascular endothelial growth factor (VEGF) . These cells were also positive for cytokeratin 18. No specimen showed cells positive for glial fibrially acidic protein (GFAP) . The finding seemed to show the involvement of VEGF from retinal pigment epithelial cells in the formation of choroidal neovascular membrane.

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