Histological features of choroidal neovascular membrane in age-related macular degeneration Hideyasu Oh 1 , Hitoshi Takagi 1 , Atsushi Otani 1 , Kiyoshi Suzuma 1 , Chikako Takagi 1 , Yu-ichiro Ogura 1 , Yoshihito Honda 1 1Dept. of Ophthalmol and Visual Sciences, Graduate Sch. of Med., Kyoto Univ. pp.1921-1926
Published Date 1998/12/15
DOI https://doi.org/10.11477/mf.1410906160
  • Abstract
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We made immunohistological studies on surgically excised choroidal neovascular membrane in 4 eyes of 4 patients with age-related macular degeneration (AMD) . We used anti-pancytokeratin to identify retinal pigment epithelial cells (RPE), anti-vascular endothelial growth factor (VEGF) to identify VEGF and anti-CD68 to identify macrophages. Staining for pancytokeratin and immunoreactivity for VEGF were positive in the periphery of neovascular membrane, perivascular cells and stromal cells. Staining for CD68 was positive in the periphery of neovascular membrane and stromal cells. The findings seemed to show that VEGF secreted from the RPE induces neovascularization in AMD and that inflammatory reactions are involved in the formation of choroidal neovascular membrane.

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