雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Histological features of choroidal neovascular membrane in age-related macular degeneration Hideyasu Oh 1 , Hitoshi Takagi 1 , Atsushi Otani 1 , Kiyoshi Suzuma 1 , Chikako Takagi 1 , Yu-ichiro Ogura 1 , Yoshihito Honda 1 1Dept. of Ophthalmol and Visual Sciences, Graduate Sch. of Med., Kyoto Univ. pp.1921-1926
Published Date 1998/12/15
DOI https://doi.org/10.11477/mf.1410906160
  • Abstract
  • Look Inside

We made immunohistological studies on surgically excised choroidal neovascular membrane in 4 eyes of 4 patients with age-related macular degeneration (AMD) . We used anti-pancytokeratin to identify retinal pigment epithelial cells (RPE), anti-vascular endothelial growth factor (VEGF) to identify VEGF and anti-CD68 to identify macrophages. Staining for pancytokeratin and immunoreactivity for VEGF were positive in the periphery of neovascular membrane, perivascular cells and stromal cells. Staining for CD68 was positive in the periphery of neovascular membrane and stromal cells. The findings seemed to show that VEGF secreted from the RPE induces neovascularization in AMD and that inflammatory reactions are involved in the formation of choroidal neovascular membrane.


Copyright © 1998, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

関連文献

もっと見る

文献を共有