Effect of laser photocoagulation on choroidal neovascular membrane and histological findings Atsushi Otani 1 , Hitoshi Takagi 1 , Kiyoshi Suzuma 1 , Hidayasu Oh 1 , Michiko Mandai 1 , Yuuichiro Ogura 1 1Dept of Ophthalmol and Visual Sciences, Grad Sch of Med, Kyoto Univ pp.737-740
Published Date 1998/5/15
DOI https://doi.org/10.11477/mf.1410905846
  • Abstract
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A 69-year-old female presented with angioid streaks complicated by choroidal neovascular membrane (CNVM) in both eyes. Her right eye was treated by laser photocoagulation and, 8 months later, by surgical removal of CNVM. The visual acuity improved to 0.6. Her left eye underwent surgery alone followed by improvement of visual acuity from 0.2 to 0.4. Recurrence of CNVM resulted in the final visual acuity of 0.08 in the left eye. Immunohistological studies of excised CNVM showed more intense immunoreactivity for vascular endothelial growth factor (VEGF) in the left eye. The findings suggest that laser photocoagulation may suppress the expression of VEGF in CNVM and may favorably affect the surgical outcome.

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