Effect of laser photocoagulation on angiogenetic factorsin choroidal neovascularization Hirokazu Ohashi 1 , Hitoshi Takagi 1 , Atsushi Otani 1 , Shinji Koyama 1 , Hideyasu Oh 1 , Seiji Kenmochi 1 , Akiyoshi Uemura 1 , Daisuke Watanabe 1 , Yoshihito Honda 1 , Yuichiro Ogura 2 , Gentaro Sugita 3 1Dept of Ophthalmol and Visual Sci, Graduate Sch of Med, Kyoto Univ 2Dept of Ophthalmol, Nagoya City Univ Med Sch 3Sugita Eye Hosp pp.622-626
Published Date 2001/4/15
DOI https://doi.org/10.11477/mf.1410907276
  • Abstract
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Purpose: To evaluate the effect of photocoagulation followed by recurrence of choroidal neovascularization (CNV) in excised specimens.

Cases and Method: Tissues were surgically removed from a 48-year-old female with idiopathic CNV and a 71-year-old male with age-related macular degeneration. The tissues were subjected to immunohistological studies.

Findings: In both specimens, the sites of recurrence showed profuse neovascularization. The photocoagulated sites almost lacked endothelial cells. The sites of recurrence showed enhanced activity of vasoformative factors including vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang 2) . The photocoagulated sites showed decreased activity of vasoformative factors.

Conclusion: Photocoagulation suppresses VEGF and Ang 2 and would inhibit neovascularization.

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