Role of macrophages in choroidal neovascular membrane Hideyasu Oh 1 , Hitoshi Takagi 1 , Atsushi Otani 1 , Kiyoshi Suzuma 1 , Chikako Takagi 1 , Yoshihito Honda 1 , Yuichiro Ogura 2 1Dept of Ophthalmol and Visual Sci, Graduate Sch of Med, Kyoto Univ 2Dept of Ophthalmol, Nagoya City Univ pp.405-408
Published Date 1999/3/15
DOI https://doi.org/10.11477/mf.1410906249
  • Abstract
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We performed immunohistochemical studies of choroidal neovascular membrane which was surgically excised in 9 eyes and which was paraffin-embedded. We tried to detect macrophages and inflammatory mediators, IL-1b and tumor necrosis factor-a (TNF-a), which are presumably derived from macrophages. Macrophages were present in the retinal pigment epithelium (RPE) layer, perivascular areas and, most conspicuously, in the stroma. Both cytokines were distributed in the RPE layer, newly formed vessels and stromal cells. I1-1b showed responderant expression in newly formed vessels. TNF-a was present in newly formed vessels and in the RPE layer with predominant immunoreactivity. Because both cytokines have angiogenic effects in vivo, co-localization of macrophages and these cytokines in the stroma strongly suggests the potential angiogenic role of this cell type in choroidal neovascular membrane.

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