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AN AUTOPSY CASE OF POSTENCEPHALITIC PARKINSONISM : INVESTIGATION ON NEUROFIBRILLARY TANGLES IN COMPARISON WITH THOSE IN PROGRESSIVE SUPRANUCLEAR PALSY Hideo Mori 1 , Masahiro Yoshimura 1 , Toshio Mizutani 1 , Shigeki Kuzuhara 2 , Hiroshi Yamanouchi 2 , Hiroyuki Shimada 3 , Masanori Tomonaga 4 1Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology 2Neurology, Tokyo Metropolitan Geriatric Medical Center 3Pathology, Tokyo Metropolitan Geriatric Medical Center 4Department of Neuropathology, Institute of Brain Research, University of Tokyo Keyword: postencephalitic parkinsonism , progressive supranuclear palsy , neurofibrillary tangle , tau , ubiquitin , birefringence pp.553-559
Published Date 1990/6/1
DOI https://doi.org/10.11477/mf.1406900064
  • Abstract
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We report an autopsy case of postencephalitic parkinsonism (PEP). The distribution, histochemi-cal, and immunohistochemical characteristics of neurofibrillary tangles (NFTs) in the case were studied and compared with NFTs in progressive supranuclear palsy (PSP). The patient was a 78-year-old woman who had suffered from "sleeping sickness" at age 27 and parkinsonism developed 13 years later. NFTs were found in the brainstem, basal ganglia, subthalamus, hypothalamus, thalamusand hippocampus in addition to marked degenera-tion of the substantia nigra. In the brainstem, NFTs were found not only in the amine-containing neurons but also in the pedunculopontine nucleus, which was recently reported to have cholinergic neurons. NFTs were immunostained by anti-bodies against tau and ubiquitin, both of which have been identified as antigenic components of NFTs in Alzheimer's disease and also those in PSP. Ultrastracturally, NFTs were composed of paired helical filaments. In serial sections with stained with Congo red and Bodian stains, all NFTs visible with Bodian stain in the brainstem of the case seemed to have Congo red birefrin-gence which is produced by β-sheet conformation of protein. In contrast, in three cases of PSP, less than half of NFTs seemed to have birefringence. These findings suggest that the protein components of NFTs in PEP and PSP are common to each other, but the conformation of the protein of some NFTs in PSP may be different from those in PPE.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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