Japanese

Nocturnal hypoxia and treatment in the patients with Duchenne muscular dystrophy Susumu Ohtake 1 , Ryujirou Nakamura 1 , Katsuro Igarashi 2 , Tadayuki Kuronuma 2 , Nobuo Koide 2 , Yoshimi Akimoto 3 , Hiroharu Kubota 3 1Department of Orthopedic Surgery, Iwaki Byoin National Sanatorium 2Department of Pediatrics, Iwaki Byoin National Sanatorium 3Department of Internal Medicine, Iwaki Byoin National Sanatorium Keyword: 夜間低酸素血症(nocturnal hypoxia) , Duchenne型筋ジストロフィー症(Duchenne muscular dystrophy) , 睡眠時無呼吸症候群(sleep apnea syndrome) pp.463-469
Published Date 1990/5/15
DOI https://doi.org/10.11477/mf.1404900145
  • Abstract
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Overnight monitoring using pulse oximeter was performed on 10 patients with Duchenne muscular dystrophy (mean age, 22; mean %FVC, 26.6%; mean PaCO2, 54.1 Torr; mean PaO2 76.6 Torr). At the same time, spinal deformity and obesity were examined.

In 4 patients, the measurement of the chest and abdominal wall movements were performed by using a respisomnograph.

In 5 patients, nocturnal desaturation below 95% occured despite normal daylight blood gas tension.

In the other 5 patients with hypercapnea of over 50 Torr, nocturnal desaturation below 85% occured, and 3 patients required oxygen supplementation treatment using a low concentration of oxygen.

In 4 patients with hypercapnea over 50 Torr, cuirass-assisted respirators were used and they preven-ted mild nocturnal desaturation, but did not have much effect on severe nocturnal desaturation.

Nocturnal desaturation was associated not only with hypopnea and hypoventilation, but with normal chest and abdominal wall movement using cuirass-assisted respirators.

It seemed that desaturation with normal respira-tory pattern can be attrilented to ventilation-perfu-sion mismatching.

The severity of the desaturation did not always correlate to the spinal deformity and the obesity.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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