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Genetics of Duchenne muscular dystrophy and care programs in Japan Kiyotaro KONDO 1 1Department of Neurology, Brain Research Institute, Niigata University pp.693-701
Published Date 1980/8/10
DOI https://doi.org/10.11477/mf.1431905187
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Abstract

 Duchenne dystrophy is a fatal degeneration of the skeletal muscles inherited X-linked recessively in about 90% of the Japanese cases, the rest being autosomal-recessive and relatively mild clinically. Genetic analyses with 514 probands disclosed; 1) X-linked recessive heredity, 2) new sporadic mutants in 1/3 of the cases, 3) equal mutation rate in the ova and the sperms with the estimated value of 6.3×10-5 per locus per generation, 4) incidence rate of 21.7×10-5 among newborn males and 5) prevalence rate of 5.0×10-5 and the estimated number of the surviving patients of about 2,430 in Japan.


Copyright © 1980, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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