化学療法により長期生存が得られている膀胱小細胞癌

Small cell carcinoma of the urinary bladder：A case report

症例は67歳，女性。血尿を主訴に当科を受診した。膀胱全摘術および回腸利用新膀胱造設術を行い，組織結果は小細胞癌であった。術後PE療法を3コース行ったが再発し，腫瘍摘出，放射線治療，PE療法3コースを行った。その後再々発しPE療法を行ったが再発病変が増大し，イリノテカンを含む化学療法を行い奏効した。現在イリノテカン単独療法を継続し，初発より8年半の長期生存が得られている。

A 67-year-old woman visited our hospital for the macro hematuria. She had the invasive bladder cancer,and underwent total cystectomy with ileal neobladder. The final histological diagnosis was small cell carcinoma of the urinary bladder. Despite of the chemotherapy with carboplatin and etoposide,local recurrence developed. Later,recurrent tumor resection,radiation therapy and further chemotherapy（etoposide and cisplatin）were performed,which again resulted tumor,recurrence. Another course of chemotherapy was again unsuccessful. New chemotherapy with CPT-11 was then administered and was finally successful,and CPT-11 has now been continued exclusively. She has been alive for over 8 years since the initial operation.