超低出生体重児の未熟児網膜症発症率と治療率

Incidence and severity of retinopathy of prematurity in very low birthweight infants

目的：出生体重が1,000g未満の超低出生体重児での未熟児網膜症の発症頻度，治療を要した頻度（治療率），発症と進行に関する因子の検討。対象と方法：2003年までの3年間に当院新生児科に入院した超低出生体重児のうち，眼底検査を行い経過が追えた60例60眼を対象とした。両眼発症の場合には，より進行した眼を選んだ。進行例には光凝固を行った。結果：網膜症は90％に発症した。光凝固は32％に施行した。発症は在胎週数，人工換気日数，酸素投与日数と相関し，出生体重とApgarスコアには相関しなかった。治療率はいずれの項目とも関連しなかった。結論：今回の検討項目については，超低出生体重児での未熟児網膜症の進行悪化に関連する因子を同定できなかった。

Purpose：To identify factors related to occurrence and severity of retinopathy of prematurity（ROP）in very low birthweight infants. Cases and Method：This retrospective study was made on 60 eyes of 60 infants who were admitted to our neonatal intensive care unit during 3 years through 2002. All the infants were born weighing 1,000g or less. In bilaterally affected cases,the more advanced eye entered the study. Cases with advanced ROP were treated by photocoagulation. Findings：ROP was present in 90％ of infants. Photocoagulation was performed on 32％ of infants. Presence of ROP was correlated with gestational age,duration of artificial ventilation,and total oxygen administration. It was independent of birthweight or Apgar score. None of above factors was correlated with severity of ROP. Conclusion：No factor could be identified as related to incidence or severity of ROP in very low birthweight infants.