耳鼻咽喉科領域におけるEndoxan, Toyomycinの使用経験

AN EXPERIENCE IN THE USE OF ENDOXAN AND TOYOMYCIN IN THE FIELD OF OTOLARYNGOLOGY

　Ⅰ．緒論

　悪性腫瘍に対する治療法としては外科的療法と放射線療法が主役であるが，化学療法の占める割合も，近年その重きを増して来た。制癌物質としては多数のものが発見され，その使用経験も数多く発表されている。私達もアルキル化剤たるNitrogen-mastardの誘導体であるEndoxanと，Streptomyces griseus No. 7の生成物たる抗生物質Chromomycin A₃（Toyomycin）を悪性腫瘍に対して使用し，若干の知見をえたのでここに報告する。

　Endoxan and toyomycin were used either alone or in combination in treatment of 14 cases of malignant tumors. The dosage of endoxan was 100 mgs per day with the total of 1,300 to 4,500 mg and toyomycin 500γ per day with the total of 11,000 to 30,000γ.

　In 50 percent of cases the agent appeared to be effective. Anemia, leucopenia, loss of appetite and diarrhea were seen as symtoms of side-effects but, when toyomycin alone was administered there was no side effects. A combined usage of these agents appeared to be more effective than when they were given singly.