ストレプトマイシンを使用せる腎結核患者20例の聴覚検査成績

　Ⅰ．緒言

　ストレプトマイシンの副作用のうち聴覚障碍は現在有効な治療法なく概ね非可逆的であるため，最も不快なるものである。この聴覚障碍の成立には，投与法，投与量，薬物の種類の他，個人的素因として先天的並に後天的或は病的因子が関与することは諸家の観察からも容易に推定出来る。我我はストマイに因る聴覚障碍の成立に関与する之等諸因子を究明し，予防に資する臨床的研究の一環として，後天的因子として腎障碍のある場合につき調査を行つたので報告する。

Mukuno and Sueyoshi find 14 cases of he-aring disturbances (70%) among 20 patients treated with streptomycin for tuberculosis of the kidneys. Hearing disturbances occured in all cases in whom the use of streptomycin exceeded 60 grams or over. Such disturba-nces began with reception of C⁶ with a gradual inclusion of C⁵ and C⁴; other cases showed a delayed effect with disturbances occurring in the 7th month after the medication had been stopped. The authors opine that, from inve-stigation of other side-reactions that accompa-ny the use of streptomycin and of the quest-ion of inherited weakness that might be effe-cted by parental inter-marriage, the occurr-ence of hearing disturbance may be two fac-tors, one of which in that the blood being taxed with relatively high concentration of streptomycin by poor elimination due to fun-ctional disturbances in the kidneys, and the other, the ear itself may be vulnerable to external attacks by lieu of inherited charact-eristics.