耳性腦膿瘍腦膜炎とオーレオマイシン

　最近の抗生物質の進歩は蓋し著しいものがあり細菌感染疾患に対して一大変革をもたらしたが，我科領域に於ても殊に急性中耳炎治療に対してもその事は云えるのであつて急性乳樣突炎手術が激減して来ている事並にその重篤なる頭蓋内合併症の予後も極めて良好となつて来ている事は事実である．併し乍らその反面にこうした抗生物質使用の為めに臨牀症状の隠蔽又は変貌に依り適切な外科的侵襲の時期を逸し或は菌の耐性獲得の為めに予後を悪化せしめる問題も漸く強く注目されて来ている．

　著者は慢性中耳炎に合併した脳膿瘍症例に於て当初より適切なる手術治療を施したと考えられるに拘らずペニシリン（以下ペ剤と称す）．抵抗性を獲得せる為か遂に脳膜炎を惹起し殆ど絶望かと思われたがオーレオマイシン（以下オマを）投与する事に依つて幸い救い得たので報告し諸賢の御参考に供し度いと思う．

SASAKI AND MIYATA report a case of me-ningitis of otic origin which responded with recovery by use of aureomycin after other means of treatment seemed to have completely failed, A man aged 27 affected with chronic cholesteatomatous otitis media developed meningitis which was caused dy staphylococcus albus and non-hemolytic streptococcus. A radical mastoidectomy was performed for draina-ge of the meningeal abcess and to facilitate that dr-ainage a glass tube was employed instead of the usual rubber dams, Penicillin was used 9,150,000 units intramuscularly, in the operative wound as well as the abcess cavity of the meninges. The bacteria which was recovered and isolated showed resistance to penicillin 20 to 30 times more those otherwise obtained. The patient appeared hopeless but when aureomycin was given by mcutn in doses of 250 mg every 4 hours he soon showed signs of improve-ments and, in 12 days when the total amount of the agent. 13,25 g, was administered ten patient was completely recovered.