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緒言
最近スルフオンアミド剤(ス剤),ペニシリン(ペ剤)の普及に依つて中耳炎並びに耳性頭蓋内合併症に対して顕著な治療的效果を示し,従来難治とされていたムコーズム菌性中耳炎特に同菌に依る化膿性腦膜炎に就いても其の治験例を散見する樣になつた.併し乍らス剤.ペ剤に対して細菌が抵抗性を獲得する事があるのは周知の事實であつてこの事は之等藥剤使用に対して充分考慮すべき事であると思われる.私等はムコーズス菌性中耳炎の診断の下に長期間乾燥療法を行いス剤及びペ剤の併用療法を行つたが全治せず,遂に乳樣突起削開術を行つたが,術後化膿性腦膜炎を合併し側頭骨蜂窠の徹底的除去,リコール持續排除,ペの大量投与も全々效果が無く重篤な症状を呈し一時は全く予後不良と思わせたが幸にもオーレオマイシン使用に依つて急性に解熱治癒におもむいた症例を經験したので其の経過の大要を述べ諸賢の御参考に供し度いと思う.
IWAMOTO AND KIMURA report their success in cure of meningitis by use of aureomycin. When administration of penicillin in large amounts failed to after the course of meningitis that began as complications of mucosus otitis media which required radical mastoidectomy aureomycin was given to the patient in dosage of 1 gm. per day divided into 4 eaoual parts. After 3 days of administration of this drug the temperature became normal and the patient made an uneventful recovery thereafter.
Authors cite various reports made by others on the subject and comment upon the dosage and sidereactions of the this antibiotic. They emphasize strongly the use of this agent whenever a case appears to become irresponsive or resistant to use of penicillin.
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