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Flow Cytometric Studies of Human Brain Tumors:Part 2: Human benign brain tumors Keiji KAWAMOTO 1 , Tadashi NISHIYAMA 1 , Yutaka IKEDA 1 , Yasuo KAWAMURA 1 , Hiroshi MATSUMURA 1 , Asao HIRANO 2 , Fritz Herz 2 , Robert C. Wolley 2 1Department of Neurosurgery, Kansai Medical University 2Department of Neuropathology, Montefiore Hospital and Medical Center, Albert Einstein College of Medicine Keyword: Flow cytometry , Cell cycle , DNA.Benign brain tumor pp.1017-1022
Published Date 1981/8/10
DOI https://doi.org/10.11477/mf.1436201380
  • Abstract
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This report compares the DNA content distribution of normal human brain tissue and of benign tumors of the brain. The cells were obtained from seven normal specimens and from fourteen types of benign brain tumors of 79 patients. The DNA content was determined by flow cytometry on single cell suspensions. Propidium iodide was used as DNA-intercalating fluorochrome. Normal, non-stimulated lymphocytes served as diploid controls.

The proportions of diploid cells in G1 ranged from 78% to 93% and from 80% to 95% in the normal cortex and normal white matter, respectively. In the specimens of benign brain tumor the range was from 70% to 98%.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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