海綿状脳症の動物接種実験（第2報）電顕的観察

Transmission experiment of spongiform encephalopathy. II. Ultrastructural observation

I．はじめに

　広汎な白質病変とkuru斑を伴なった亜急性海綿状脳症例の脳乳剤を用いた接種実験により，マウスおよびラット脳に海綿状態が発現したことを，われわれは前に報告した。これまでに，とくに動物の臨床症状，接種から発症までの期間，中枢神経系病変の分布などを中心に述べた^20,21）。ここでは神経病変の電顕的所見，とくに灰白質と白質それぞれに存在する空胞の性状について報告し，それらの空胞の発生・発達について考察を加える。

Abstract

We had previously reported that a human spongiform encephalopathy with kuru plaques and leukomalacia was directly transmitted to rats and mice. Present study is dealt with electron microscopic observations of the vacuoles in the cerebral cortex and the white matter of these animals. For this study, clinically affected animals, fifteen CF #1 mice and seven Donryu rats, were examined in the first or subsequent passages. In order to see initial morphological changes in the brain, two mice each were sarcificed every week from one to fifteen weeks after inoculation.