中心前回に海綿状態とAstrocytosisを伴なう著明な萎縮を認めた筋萎縮性側索硬化症

A case of amyotrophic lateral sclerosis with severe motor cortex lesion

　筋萎縮性側索硬化症（ALS）の病因を考えるにあたって，上位および下位運動ニューロンのどこに初期病変が起こるのかは，なお未解決であるが，中心前回の病変は脊髄での病変に劣らず重要で注目すべきことを示唆する症例を経験したので報告する。

Abstract

Clinical and pathological findings of 51-year-old high school teacher was reported, who presented a classic form of ALS. His initial symptoms were spastic gait and distal muscular atrophy of the right upper extremity. Dysarthria, dysphagia and atrophies of muscles in the upper and the lower extremities followed. Deep reflexes were hyper-active, and extreme rigido-spasticity of the muscles in all extremities made him unable to move in a short course. He showed no mental deterioration or other mental symptoms except occasional emotional incontinence.