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I.緒 言
老化とamyloidとの関連については,比較的古くから多くの論議がなされている。
脳の老化に関連してamyloidが重視される理由は,脳の老化を特徴づける形態学的表現の一つである老人斑にamyloidの沈着が認められること4),老人脳の血管壁にamyloidの沈着により22),老人斑様血管変化drusige Entartungに至る血管病変が認められ21),老人斑の成因に深い関連が考えられてきたことにある22)。
Abstract
Clinicopathological features with electron micro-scopical findings of an unusual case of presenile dementia were reported.
Clinically, a 39 years-old man began to com-plain of low back pain and leg pains and deficulty in walking and then he developed mental dis-turbances such as depressive mood change and personality change. He became increasingly demented and deteriorated and expired in the apallic state 2 years and a half after the onset of his illness.
Macroscopically, the weight of the brain was 1,450gr. The leptomeninges over the convexities were to some extent opaque and only slightly thickened.
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