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Expeimental transmission of Creutzfeldt-Jakob disease and isolation of pathogens. Jun TATEISHI 1 , Tetsuyuki KITAMOTO 1 , Takatoshi TASHIMA 1 , Shirou MOHRI 2 1Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University 2Laboratory of Animal Experiments, Faculty of Medicine, Kyushu University pp.87-96
Published Date 1987/2/10
DOI https://doi.org/10.11477/mf.1431905865
  • Abstract
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 Transmission experiments were done inoculating materials taken from 21 patients with Creutzfeldt-Jakob disease (CJD) and 4 with Gerstmann-Sträussler-Scheinker's disease (GSS) to various laboratory animals. 18 CJD patients and 2 GSS patients were successfully transmitted to rodents. Mice were most susceptible and developed the disease within 4 months after the second passage. Guinea pigs, rats, hamsters, Mongolian gerbils and squirrel monkeys were infected after prolonged incubation periods of this order. Mice strains resulted some differences in incubation periods, while age of mice including fetus, did not.

 The highest infectivity was found in the brains of all patients but one whose lymph node was most infectious. Spleen, kidney, cornea, blood and urine of a few patients were also infectious. Cerebrospinal fluid taken from 7 patients could not transmit the disease, though those from 2 diseased mice were infectious. Intracerebral ino-culation was the fastest route of infection, but intraperitoneal, submucosal, subcutaneous and oral routes could transmit the disease.


Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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