BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 68, Issue 6 (June 2016)
Japanese

The Importance of Vagus Nerve Afferent in the Formation of Emotions in Attention-Deficit Hyperactivity Disorder Model Rat Hideki Hida 1 1Department of Neurophysiology & Brain Science, Nagoya City University Graduate School of Medical Science Keyword: 注意欠陥多動障害 , うま味 , 発育期 , 攻撃性 , 胃迷走神経切断 , attention-deficit hyperactivity disorder , umami , development , aggression , vagotomy pp.633-639
Published Date 2016/6/1
DOI https://doi.org/10.11477/mf.1416200454
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Abstract

It is of interest to know how environmental stimuli contribute to the formation of emotion during development. In a rat model of attention-deficit hyperactivity disorder, monosodium L- glutamate (MSG), a taste substance of umami, was administered for 5 weeks during developmental period, followed by emotional behavior tests such as open-field test and social interaction test in adulthood. Although no significant change was observed in anxiety-like behavior, MSG intake caused a reduction in aggressive behavior. Vagotomy under the level of diaphragm resulted in eliminating the MSG effect on aggression, indicating the importance of neuronal activity of the vagus nerve in this effect. Futher studies will focus on futher questions regarding the gut-brain axis such as the change of microbiota and the mechanism of the axis in the brain.


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基本情報

18816096.68.6.jpg
BRAIN and NERVE-神経研究の進歩
68巻6号 (2016年6月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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