BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 68, Issue 6 (June 2016)
Japanese

  • Abstract
  • Look Inside
  • Reference

Abstract

Gene-microbiota interactions are now proposed to be a special case of gene-environmental interaction. Preclinical and clinical data summarized in this article reveal that a specific serum metabolite, associated with alterations in gut microbiome composition, might have an emerging role in the onset and pathogenesis of autism. Altered level of this specified metabolite may induce perturbations in the epigenome and modulate the expression of key disease susceptible genes in neurons and their associated cells during critical periods of neurodevelopment. The gut microbiota itself is now regarded as a reservoir for environmental epigenetic factors.


Copyright © 2016, Igaku-Shoin Ltd. All rights reserved.

基本情報

18816096.68.6.jpg
BRAIN and NERVE-神経研究の進歩
68巻6号 (2016年6月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

関連文献

もっと見る

文献を共有