BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 68, Issue 6 (June 2016)

Depressive Disorder and Gut-brain Interaction Hiroshi Kunugi 1 1Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry Keyword: うつ病 , ストレス , プロバイオティクス , 腸内フローラ , 腸の透過性 , depressive disorder , stress , probiotics , gut microbiota , gut permeability pp.641-646
Published Date 2016/6/1
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Depressive disorder is a stress-induced condition, which has been suggested to have bidirectional interactions with the gut microbiota. Probiotics such as Bifidobacterium and Lactobacillus have been suggested to mitigate stress response. Irritable bowel syndrome (IBS) is a typical phenotype of psychological distress manifested in the gastrointestinal system, and often develops in patients with depressive disorder. The altered gut microbiota and resultant inflammation in the gut play an important role in at least a portion of IBS. Animal models of depression have shown abnormalities in the gut such as increased gut permeability, and the probiotics ameliorate their chronic depression-like behaviors and altered stress responses. There have been only a few studies that have directly investigated the gut microbiota in patients with depression. We reported results suggesting that individuals with lower bacterial counts for Bifidobacterium and/or Lactobacillus are more common in patients with major depressive disorder than in healthy controls. the collectively use of gut microbiota in the diagnosis and treatment of depressive disorder seems to be a promising approach.

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BRAIN and NERVE-神経研究の進歩
68巻6号 (2016年6月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院