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Japanese

Trazodone for the Treatment of Behavioral and Psychological Symptoms of Dementia(BPSD)in Alzheimer's Disease : A Retrospective Study Focused on the Aggression and Negativism in Caregiving Situations. Yoko Kitamura 1 , Yuri Kudo 2 , Toru Imamura 1,2 1Department of Speech Therapy, School of Health Sciences, Niigata University of Health and Welfare 2Department of Neurology, Niigata Rehabilitation Hospital Keyword: Alzheimer's disease , behavioral and psychological symptoms of dementia(BPSD) , trazodone , aggression , negativism pp.483-488
Published Date 2006/6/1
DOI https://doi.org/10.11477/mf.1406100380
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 Behavioral and psychological symptoms of dementia (BPSD)includes anxiety, depression, hallucination, delusion, aggression, irritability, agitation and wandering. BPSD often causes a deterioration of activity of daily living(ADL)and worsens caregiver burden. Trazodone, an atypical antidepressant, is used for the treatment of BPSD, but the effectiveness is controversial. In this study, we retrospectively analyzed the medical records of the 13 AD patients who were rated as having the aggression and negativism in caregiving situation and were treated by trazodone. The BPSD of the per-treatment stage of the patients was assessed with Neuropsychiatric Inventory(NPI). Improvement of BPSD after trazodone was observed in 9 patients, and the aggression and negativism in caregiving situations were improved in 6 patient. Trazodone may be effect for the treatment of a certain type of BPSD such as aggression and negativism in caregiving situations. Prospective studies of this issue are recommended in AD patient.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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