Effect of low-dose warfarin on retinal vein occlusions.: Report 1. Correction of blood hypercoagulability to prevent recurrence in chronic cases Toshihide Ikeda 1 , Kenji Ogawa 2 , Ken-ichiro Takahashi 3 , Kiyomi Fujii 3 , Arata Inoue 3 1Dept of Ophthalmol, Yukioka Hosp 2Dept of Ophthalmol, Toyonaka Municipal Hosp 3Dept of Ophthalmol, Sakai Municipal Hosp pp.1221-1224
Published Date 1997/6/15
DOI https://doi.org/10.11477/mf.1410908867
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We treated 23 cases of branch retinal vein occlusion by peroral warfarin at the daily dosis of 1 mg for an average of 30 days. The series comprised 18 cases of branch occlusion and 5 cases of central retinal vein occlusion. All the cases were chronic ones more than 4 months after onset. Prothrombin time decreased significantly after treatment (p<0.05), to stay within normal range in all cases but one. Thrombin-antithrombin III complex (TAT) was elevated in 16 cases (70%) before treatment. The value decreased significantly after treatment (p<0.05). It decreased to normal range in 9 cases. There was no instance of complications including hemorrhagic tendency throughout the cases. The findings suggest the possibility of correcting the hypercoagulability state in chronic cases of retinal vein occlusions by low-dose warfarin.

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