Usefulness of topical cyclosporin A following penetrating keratoplasty Yukihiro Matsumoto 1,3,4 , Mitsuko Ohyama 2,3 , Yoshiyuki Satake 3 , Jun Shimazaki 3 , Kazuo Tsubota 3,4 1Dept of Ophthalmol, Sano Kousei General Hosp 2Dept of Ophthalmol, Kyorin Univ Sch of Med 3Dept of Ophthalmol, Tokyo Dental Coll 4Dept of Ophthalmol, Keio Univ Sch of Med pp.957-962
Published Date 1998/5/15
DOI https://doi.org/10.11477/mf.1410905896
  • Abstract
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We evaluated the effect of topical instillation of 0.05% cyclosporin A in preventing graft rejection following penetrating keratoplasty in 111 eyes. Cyclosporin A was used as early substitute of topical 0.1% betamethasone in 40 eyes. The other group of 71 eyes were treated by topical betamethasone only. Graft rejection developed in 17.5% in the former group and in 9.9% in the latter. Incidence of postoperative glaucoma was 15.0% in the former group and 19.7% in the latter. The difference was not significant (p>0.05) . The overall incidences in the whole series of 111 eyes were : 12.6% for graft rejection, 93.7% for graft transparency and 18.0% for postoperative glaucoma. The findings show that topical cyclosporin A is not superior to topical betamethasone in preventing graft rejection following penetrating keratoplasty. A discrete combined use of both therapeutic regimens promises to be of value in this regard.

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