Japanese

Topical cyclosporin A in preventing allograft rejection after penetrating keratoplasty Toshiyuki Maruo 1 , Satoru Yamagami 1 , Tadahiko Tsuru 2 1Dept of Ophthalmol, The Univ of Tokyo Sch of Med 2Section of Transplantation, The Univ of Tokyo Sch of Med pp.41-44
Published Date 1996/1/15
DOI https://doi.org/10.11477/mf.1410904708
  • Abstract
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We evaluated the effect of topical 2% cyclosporin A (CsA) in preventing allograft rejection after penetrating keratoplasty in 42 eyes of 42 patients. Another series of 50 eyes of 50 patients without CsA served as control. Both groups were operated with the same surgical procedure and showed matching risk features as bullous keratopathy, neovascularization or regrafting. The rejection-free survival rate was calculated by Kaplan-Meier's life table analysis. The survival rate at 20 months was 87.3% for CsA group and 68.6% for control. The difference was significant. Topical CsA was thus effective in preventing allograft rejection after penetrating keratoplasty.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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