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Graft rejection developed in a case of penetrating keratoplasty during systemic Cyclosporine therapy Koichi Soya 1 , Kazunori Miyata 2 , Motonari Murao 3 , Mitsuru Sawa 4 1Dept of Ophthalmol Tokyo Univ Fac of Med 2Dept of Ophthalmol Branch Hosp, Tokyo Univ Fac of Med 3Dept of Ophthalmol Self-Defense Force Central Hosp 4Section of Corneal Transplantation, Tokyo Univ, Fac of Med pp.961-963
Published Date 1991/6/15
DOI https://doi.org/10.11477/mf.1410900690
  • Abstract
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A 23-year- old woman underwent repeated pene-trating keratoplasty for congenital hereditary en-dothelial dystrophy. After the second surgery for the right eye, or the 4 th for both, we administeredsystemic Cyclosporine at the daily dosis of 5 mg per kg of body weight. The dosis was reduced to 3 mg/ kg one week later. Four weeks after surgery, the plasma cyclosporine was at an effective im-munosuppressive level of 250 ng/ml. Acute rejec-tion developed one week later resulting in dysfunc-tion of corneal endothelium. It appeared that the dosis of Cyclosporine was not adequate in this particular case.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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