Effect of cyclosporine following penetrating keratoplasty Satoru Yamagami 1 , Tomohiro Ohya 2 , Tadahiko Tsuru 3 , Katsunori Ogasawara 2 , Masanobu Suzuki 2 , Koukichi Toyohara 2 , Chikako Kimura 2 , Kazunori Miyata 2 , Tsutomu Sato 2 , Mitsuru Sawa 4 1Eye Clinic, JR Tokyo General Hosp 2Dept of Ophthalmol, Tokyo Univ Med Sch 3Section of Corneal Transplantation, Dept of Ophthalmol, Tokyo Univ Med Sch 4Dept of Ophthalmol, Nippon Univ Med Sch pp.763-767
Published Date 1994/4/15
DOI https://doi.org/10.11477/mf.1410903778
  • Abstract
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We evaluated the effects of systemic cyclosporine as adjunct to topical corticosteroid in 26 eyes after high-risk penetrating keratoplasty. As standard procedure, systemic cyclosporine was administered at the daily dosis of 5 mg/kg for 2 weeks after surgery and 3 mg/kg thereafter for at least 10 weeks. Endothelial rejection occurred in one case during the therapy and in another after discontinuation. There was no instance of epithelial rejection. As side effects, 6 cases showed transient elevation in serum BUN or creatinine and 4 cases showed increase in GOT or GPT values. Elevation in BUN persisted in one case after discontinuation of therapy. No severe complications developed throughout the series. The findings suggest the efficacy and relative safety of sytemic cyclosporine for high-risk penetrating keratoplasy.

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