Retinal sensitivity of hyperfluorescent and geographic hypofluorescent lesions in age-related macular degeneration by indocyanine green angiography Miki Nishi 1 , Keisuke Mori 1 , Shin Yoneya 1 1Dept of Ophthalmol, Saitama Med Sch pp.817-820
Published Date 1998/5/15
DOI https://doi.org/10.11477/mf.1410905864
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Indocyanine green angiography on eyes with age-related macular degeneration may show intrachoroidal hyperfluorescent lesions during the conventional late phase and geographic hyperfluorescent lesions 24 hours after dye injection. The hypofluorescent areas may be located which appear normal by ophthalmoscopy. We evaluated the retinal sensitivity in 24 eyes with age-related macular degeneration using a scanning laser ophthalmoscope (SLO). The retinal sensitivity was 30.2±2.4 dB (mean±SD) in hyperfluorescent lesions. It was 30.0±2.0 dB in geographic hypofluorescent lesions. Both values were significantly lower than that in normal areas equidistant from the optic disc. The findings suggest that the metabolism between the outer retina and the choroid is impaired in these subclinical lesions.

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