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糖尿病網膜症98眼のインドシアニングリーン(ICG)螢光眼底造影所見について,ビデオ赤外眼底カメラおよび高解像度デジタル画像を用いて検討した。ICG螢光眼底造影では,フルオレセイン螢光眼底造影(FAG)で明らかな無血管野,網膜細小血管異常はみなかった。一部の毛細血管瘤,網膜新生血管ではICG螢光漏出がみられ,強い透過性亢進が示唆された。FAGでごま塩状過螢光を示した黄斑部の色素異常部はICG螢光眼底造影では低螢光として観察され,脈絡膜毛細血管の循環障害が示唆された。脈絡膜内ICG螢光漏出が観察された症例もみられた。ICG螢光眼底造影では,FAGでは捉えることができない糖尿病網膜症の脈絡膜血管障害が観察できた。
We performed indocyanine green (ICG) fluorescence angiography in 98 eyes of diabetic retinopathy, using video infrared fundus camera and high-resolution digitalized imaging system. The present system failed to document areas of capillary nonperfusion or microvascular abnormalities as is customary with conventional fluorescein fundus angiography. Some capillary microaneurysms and neovascularizations showed extravasation of indyconanine green, suggesting increased permeability. Pigmentary disturbance of the macula shown as salt-and-pepper appearance by fluorescein angiography appeared as hypofluorescent areas in ICG angiography, suggesting underlying choriocapillary circulatory disturbances. Intrachoroidal leakage of ICG was occasionally observed. The present studies show that some choroidal vascular distur-bances in diabetic retinopathy can be better detected by ICG than fluorescein angiography.
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