Virus particles in Kirisawa-Urayama type uveitis Hiroshi Inoue 1 , Masahiko Usui 1 , Michiko Hasemi 1 , Kentaro Takamura 1 , Fumiharu Seki 1 , Toshihiro Ichikawa 1 1Dept of Ophthalmol, Tokyo Med Coll pp.307-311
Published Date 1989/3/15
DOI https://doi.org/10.11477/mf.1410210654
  • Abstract
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We studied the vitreous humor samples from 5 eyes, 5 patients, with Kirisawa-Urayama type uveitis, using electron microscopy and other viral examinations. We paid particular attention to detection of virus particles as correlated with the antiviral agents and the timing of sample collec-tion.

We identified virus-like particles from 3 eyes and virus particles in 1. The particles from 1 eye showed morphological characteristics of varicella-zoster virus (VZV). We could confirm the particles to be VZV through evaluation of intraocular antibody quotient and virus antigen on the intraocular tissue.

The possibility of detection of virus particles seemed to increase when the sample is collected sooner after onset of uveitis, when systemic acy-clovir is started later, and when the total dose of acyclovir is lowered.

Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.


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