Lymphocyte subsets in the iris tissue with uveitis Shigehisa Nonaka 1 , Kentaro Takamura 1 , Hiroshi Goto 1 , Jun-ichi Sakai 1 , Masahiko Usui 1 1Dept. of Ophthalmol, Tokyo Med Coll pp.447-451
Published Date 1986/5/15
DOI https://doi.org/10.11477/mf.1410209702
  • Abstract
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We conducted an immunohistological study on iris tissue obtained from 13 eyes with uveitis to determine lymphocyte subsets using monoclonal antibodies. The series included Vogt-Koyanagi-Harada disease (4eyes), sympathetic ophthalmia (2), Behget disease (2) and uveitis of unknown etiology (5). The tissue speci-mens were obtained during surgery for complicated cataract. Normal iris tissues were also obtained during surgery for senile cataract and were used as controls.The tissues were processed by staining using the en-zyme-labelled antibody method with monoclonal anti-bodies for OKT4, OKT8 and OKT11 to analyze the lymphocyte substes.

In all the tissue specimens with uveitis, the iris was infiltrated more with OKT8-positive cells than with OKT4-positive ones. T-lymphocyte subsets were almost absent in normal iris tissues.

These findings to indicate that suppressor-cytotoxic lymphocytes are prominent in the iris during the chronic stage of uveitis and that they play a role in suppressing the recurrence of inflammation.

Rinsho Ganka (Jpn J Clin Ophthalmol) 40(5) : 447-451, 1986

Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.


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